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While controlled clinical trials are limited, anecdotal and preliminary data suggest multiple benefits: Skin Rejuvenation: Many patients notice firmer, smoother skin after treatment

Furthermore, IGFBPs other than IGFBP-3 may play a role in the access of IGF-I to various tissues (129)

Cycling Approach: Some practitioners implement protocols such as 12 weeks on, 4-8 weeks off to theoretically prevent receptor desensitization, reduce long-term costs, or provide physiological breaks