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This observation is consistent with the DRB1*15:01 allele belonging to one of the three oldest ancestral haplotypes (DR2-DQ6, DR3-DQ2, and DR4-DQ8), which have survived over time due to their ability to recognize a greater diversity of antigens, allowing them to detect and eliminate a greater number of pathogens (113, 114)

MS spectra of oxidative biomarkers in herniated nucleus pulposus and nonherniated nucleus pulposus measured by the high-resolution mass spectrometry

In the case of using 5% TFA, 7% change from control was determined in variants of buffer and serum (Fig

Diagnosis of Neurofibromatosis Type 1 Currently, diagnosis of NF1 is still mainly based on clinical observations.53 However, the timing of development of diagnostic criteria hinders diagnosis in small children and, in fact, only 46% of patients with no family history of the disease are diagnosed before the age of 2 years.54 In recent years, several authors have proposed the inclusion of other cutaneous findings such as NAs and xanthogranulomas in the diagnostic criteria to facilitate diagnosis in this age group,25,7,27 and some authors go as far as to propose a revision and update of the classical clinical criteria.27,55 Genetic diagnosis of NF1 is not generally available

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