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In the collecting tubule, NH 3 combines with exported H + to form NH 4 + , which is excreted in the urine

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In our study, RNA-seq of RTECs with REST knockdown under HR, primary RTECs of mice with Rest knockout, histological examination of Rest RTKO mouse kidneys, and TEM observations collectively demonstrated that ferroptosis was one of the key regulatory pathways through which REST contributed to AKI-to-CKD transition

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However, a number of small case-control studies lacked the statistical power to detect modest associations with exposure to trichloroethylene (Jensen et al