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During weight loss and metabolic shiftcommon experiences in GLP-1 therapycells may experience transient oxidative stress as energy metabolism increases and adipose tissue remodeling occurs

O'Sullivan JDB, Nicu C, Picard M, et al

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( A ) HCT116 and SW480 cells were treated with RSL3 (1 and 5 M) or DMF (25 and 100 M) alone or in combination with FG4592 (100 M) with or without ferroptotic inhibitors Fer-1 (0.5 M) or Lip-1 (1 M) for 24 hours, and cell death was assayed