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DOI: 10.1016/j.mce.2010.07.007 [13] Pfaus, J.G

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Bath-Hextall FJ, Matin RN, Wilkinson D, Leonardi-Bee J

community and clinical sources describe dermatological monitoring for these changes, especially with long-term use Injection site darkening localized hyperpigmentation Mood changes irritability reported by some during loading Managing nausea: community sources commonly describe beginning at 100-250 mcg, injecting before bed on an empty stomach, using anti-nausea medication (ondansetron) when needed, and escalating the dose gradually