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Introduction The diagnosis of Parkinson's disease (PD) in live patients is fundamentally clinical, and is based on the presence of its cardinal signs (rest tremor, rigidity, bradykinesia, and postural instability), and the absence of atypical data for idiopathic PD

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Other stabilizations of protein chains, RNA, and DNA are provided by the pairing of polar groups (S proton acceptors and SH donors, and SS bridges)

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Presence of the rare minor allele re3583882 (p.R215W) in the transcobalamin gene is also associated with unmeasurable levels of holoTC in serum