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10.1073/pnas.1220998110 102 KurowskiM

The role of cell signaling in the crosstalk between autophagy and apoptosis in the regulation of tumor cell survival in response to sorafenib and neratinib

Because Ggt1 overexpression and abnormal glutamate accumulation damage cells, these excess glutathione conjugates must be cleared from the cell, followed by subsequent glutathione metabolite recycling to protect the system from toxin-induced kidney impairment and maintain the redox balance

Lipid peroxidation is induced by hydroxyl, peroxyl, and alkoxy radicals that destroy the lipid membrane by interacting with the methylene group of fats

These include cathepsin S, B-cell-activating factor, and myxovirus resistance protein A (Nishikawa 2016

Consistent with its important role in controlling MG detoxification, glyoxalase system dysfunctions have been associated with various brain pathologies and in particular neurodegenerative diseases (Ramasamy et al., 2005