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Furthermore, inefficiencies in oxidative phosphorylation due to leakage of protons across the mitochondrial membrane and slippage of the ATP synthase/proton pump commonly reduces the ATP yield from NADH and FADH 2 to less than the theoretical maximum yield

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(B) Figure shows mitochondrial perimeter and form factor (branching) analyzed from the mitochondrial micrograph

Therefore, cancer cells develop rewired metabolic pathways through genetic mutations or the activation of innate recycling machinery in order to meet the increased requirements for proliferation 7,21

In normal red blood cells, pentose phosphate pathway and glycolysis are enhanced and G6PD is sufficient to produce NADPH efficiently for GSSG reduction and maintenance of GSH pool (311)