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When ROS levels rise, they initiate a chain reaction that leads to the formation of lipid peroxides

It indicates that the two TM helices (13-18, 24-28, 67-71, 77-81, 82-86) and the immediate cytosolic regions next to them (2-7, 87-91, 93-96) are crucial for LYSET function

Notably, these findings were observed without clinically significant weight loss

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In addition, deletion of mip resulted in reduced motility as well as protease production and attenuation in a BALB/c mouse model [Citation170]