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Mitochondrial function naturally declines with age, and it is directly linked to reduced energy, slower metabolism, and increased susceptibility to age-related diseases

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All descriptions refer exclusively to research characteristics , not biological outcomes

Accessed 12 Nov

Mar 14 2019;3(3):CD007411

Health economics Older adults living with severe obesity have increased healthcare use and cost [22], although the effect of obesity on years-of-life-lost is greatest in younger adults, and the magnitude of years lost with obesity decreases with ageing [16], irrespective of sex, smoking status, physical activity level, or socioeconomic status [35], complicating the health economic considerations of obesity management in older adults