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3f, g), indicating again the lack of involvement of the Sec-containing C-terminus in the mechanism of action of these TGR inhibitors

c , Amide- 15 N-glutamine and 15 N 2 -uridine tracing to UMP in NHA donor #1 cells cultured in HPLM without dialysed FBS and with epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) ( n = 3)

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studies have confirmed the upregulation of HIF-1 and its target genes, such as pyruvate dehydrogenase kinase 1 (PDK1) and lactate dehydrogenase A (LDHA), specifically within the CD68+ macrophages infiltrating the kidneys of LN patients and lupus-prone mice ( Complex positive feedback loops exist between glycolysis and innate immune signaling pathways, exacerbating the inflammatory storm in LN