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Studies have shown that propofol can increase the levels of ferritin heavy chain-1 (FTH1), xCT, or GPX4, improve the antioxidant capacity of cardiomyocytes via iron level reduction and inhibit cell ferroptosis through the AKT/P53 signalling pathway (Li et al., 2022)

Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, et al

Ramkumar M, Rajasankar S, Gobi VV, Janakiraman U, Manivasagam T, Thenmozhi AJ, Essa MM, Chidambaram R, Chidambaram SB, Guillemin GJ (2018) Demethoxycurcumin, a natural derivative of curcumin abrogates rotenone-induced dopamine depletion and motor deficits by its antioxidative and anti-inflammatory properties in parkinsonian rats

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Curcumin (200 mg/kg) significantly ameliorated brain injury and neurological deficits in rats subjected to middle cerebral artery occlusion by upregulating autophagy-related proteins p-Akt and p-mTOR, while downregulating autophagy-associated proteins LC3-II/LC3-I and inflammation-related proteins IL-1, TLR4, p-38 and p-p38