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In models of neuronal damage and cognitive impairment induced by the chemotherapeutic agent MTX or surgical intervention, MSCs-Exos significantly ameliorated oxidative stress, ferroptosis, and neurological function through activation of the Nrf2-ARE or SIRT1/Nrf2/HO-1 pathways [124, 125]

Tindle et al., 2021

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Most true peptides are not orally bioavailable because stomach acid and digestive enzymes break down amino acid chains before they reach systemic circulation