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Sixty patients aged 65 and older were randomly assigned to either a loading dose regimen (daily administration for 14 days followed by weekly doses) or a regimen without a loading dose (administration every 3 days) over 90 days

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This effect is believed to be due to IGF-1 suppression of insulin secretion, which leads to augmented lipolysis in adipose tissue and promotion of FFA use by muscle

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Metabolites , 14.