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A more recent advance is mtDNA base editing, which utilizes engineered deaminase enzymes (e.g., DddA-derived cytosine base editors) to catalyze CG to TA base conversions in double-stranded mtDNA without creating double-strand breaks

Evaluation with isodynamic time-measuring method and acupuncture treatment with muscle-region needling for limb spasm

CNS-restricted transduction and CRISPR/Cas9-mediated gene deletion with an engineered AAV vector

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Timeline for Visible Results: Week-by-Week Progress During the first two weeks of treatment, patients may notice subtle improvements in skin texture and brightness, though significant pigmentation changes are not yet visible

It can decrease bone mineral density, especially in the first 2 years of use