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In silico mutagenesis examinations further underpin the molecular basis of HI/HA dominant mutations and consequent over-activity of GDH through alteration of this allosteric communication network

Se, through GSH reductase and other selenoproteins, regulates the antioxidant activity in cells, thus protecting the human body against harmful effect of free radicals and, conse- quently, reducing the risk of cancer [ 47 , 48 ]

DiDang decoction (DDD) is a TCM formula comprising rhubarb, peach kernel, leech, and gadfly, known for its ability to break up silt

Prominent features include subchondral bone cysts, also known as intraosseous lesions, that form in regions subjected to repetitive mechanical overload