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To view a copy of this licence, visit About this article Cite this article Cong, R., Deng, C., Li, P

Melatonin inhibits the development of endometriosis by disrupting mitochondrial function and regulating siRNA expression in mouse models (137)

Notably, in these studies, the upregulation of GPx4 has been achieved by using exogenous agents (like NVP-AUY922, Bafilomycin A1, PD151746, GsMTx4, epigallocatechin-3-gallate, total flavonoids of Engelhardia roxburghiana leaves, Lycium barbarum polysaccharide-glycoprotein, perillaldehyde, melotonin, ferulic acid, and sphingosine-1-phosphate) which either inhibit the degradation of GPx4 or increase its transcription by activating the Nrf2 [67]

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These discrepancies may stem from differences in study design, dosage, duration of supplementation, and baseline nutritional status of participants

Flores, H., Lin, S., Contreras-Ferrat, G., Cronan, J