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doi:10.3340/jkns.2010.48.5.429

As a result, the BBB becomes more permeable, and the TJs are disturbed [53]

Importantly, the proteomic similarity of Day 30 iHLOs to PHHs, with a 33.46% expression difference from liver tissue, underscores their physiological relevance compared to traditional models like HepG2 cells, which exhibit a 54.36% protein difference from liver tissue, or HepaRG cells, with a 45.40% protein difference