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[DOI] [PMC free article] [PubMed] [Google Scholar] 184.Lu WC, Xie H, Yuan C, Li JJ, Li ZY, Wu AH

Finally, we summarize strategies to interrupt key mechanisms that cause OSF, including modulation of the ECM, inhibition of inflammation, improvement of vascular disturbance

Araliadiol may have an effect similar to other polyalkynes owing to its polyacetylene structure, but its mechanism requires further study

In clinical translation, robust multi-center preclinical studies with large sample sizes are essential to verify drug efficacy and safety