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After four weeks, those treated with Pycnogenol, at dosages of either 150 mg or 100 mg daily, had increased cochlear blood flow in the affected ear and reduced tinnitus severity, and the effects were more pronounced in those receiving the higher dosage

The actual milligram dose depends entirely on the concentration of the solution

The fact that reduced glutathione is such a reactive substance it is best to use an IV push rather than an IV drip to facilitate better and faster absorption into the bloodstream

10.1007/s10535-012-0042-1 165 SongW

Also, the addition of pharmacodynamic markers (including serum, cellular, or tissue concentrations of TNF-alpha and IL-8) might boost the predictive performance of models and, eventually, control the disease with a significant improvement in quality of life (QOL)

doi: 10.18632/oncotarget.11273