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The selected dose of 120 mg/kg body weight is a well-established one for inducing significant and consistent testicular oxidative stress and spermatotoxicity in rodent models, as extensively documented in the literature 39

Emsley John

(2007) Sulfiredoxin, the cysteine sulfinic acid reductase specific to 2-Cys peroxiredoxin: its discovery, mechanism of action, and biological significance, Kidney Int

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Africa Organization for Research and Training in Cancer

During this initial hyper-inflammatory phase with associated tissue hypoxia, the PRR (Toll-like receptors) upregulate a number of proliferative pathways such as NF-B, hyper activation of NLRP3 inflammasommes, mitogen-activated protein kinase (MAPK), and mammalian target of rapamycin (mTOR) that trigger the cytokine storm [23,24,25]