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Elimination: Renal clearance may account for about 30% of the total body clearance

Evans et al., Fever and the thermal regulation of immunity: the immune system feels the heat, Nature Reviews Immunology, doi:10.1038/nri3843

Its analgesic and antipyretic properties stem from two key mechanisms: selectively inhibiting COX (Cyclooxygenase) enzymes in the brain to block PGE2 prostaglandins (the fever and pain-signaling chemicals), and newer theories suggest a contribution from an active metabolite called AM404