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Genetic deletion of optic atrophy 1 (OPA1) in neutrophils, a mitochondrial inner membrane protein, impaired the activity of mitochondrial electron transport complex I and destroyed NAD + regeneration, consequently reducing available NAD + levels, and hence the rate of glycolysis, thereby resulting in decreased ATP production and thus breaking the formation of neutrophil extracellular traps [83]

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doi: 10.1053/j.gastro.2007.01.033 29

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