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Discordance Between Endocrine and Paracrine/Autocrine IGF-I An important example of metabolic and mitogenic consequences of an unbalanced endocrine versus autocrine/paracrine insulin-GH-IGF-axis comes from observations in children and adolescents with type 1 diabetes (Figure 5)

Common side effects: Injection site discomfort Mild diarrhea Hot flashes Dizziness or itching Precautions: Avoid B12 injections if youre allergic to cobalt or have Lebers hereditary optic neuropathy