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In fact, earlier study reported that SUN significantly decreased P-ACC2 protein expression secondary to the inhibition of AMPK in mice treated with SUN and in cardiac myocytes in culture [17]

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doi: 10.1136/thoraxjnl-2017-210305 56 DelucchiKFamousKRWareLBParsonsPEThompsonBTCalfeeCS

This begins with assessing the methodology used, given the variability across approaches