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Highlights: RT-AM is cell permeable and can generate RT upon intracellular esterase cleaveage Easily quantitate GSH levels in live cells using confocal microscopy/FACS Signals from blue and green channels allow for deduction of GSH concentration, given appropriate calibration curve For calibration curve, see: RealThiol (RT) Glutathione (GSH) Calibration Probe Subcellular detection and localization of GSH is important in understanding the modulation of redox status, the effect of drugs, and the mechanisms of detoxification

Early-generation HSP-90 inhibitors display major gastro-intestinal adverse effects, sometimes causing trial termination

284,285,286 Moreover phase I clinical trial has shown that the combination of DSFCu and temozolomide has an acceptable safety profile and increases progression-free survival in patients with glioblastoma 287 (Table 1)

tamoxifen citrate (Sigma Aldrich, Saint Louis, MO, United States)

Metformin, commonly prescribed for type 2 diabetes, can interfere with B12 absorption, and the MHRA advises considering periodic monitoring for patients on long-term metformin therapy, particularly those with risk factors for deficiency

Retrieved July 5, 2008