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Rural status is defined for purposes of this analysis using the primary Rural-Urban Commuting Area (RUCA) codes 4-10 (including micropolitan, small town, and rural areas) corresponding to each beneficiary's zip code

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Traditionally, cell death resulting from IR has been categorized as apoptosis (or Programmed Cell Death (PCD) type I), autophagy (or PCD type II), or necrosis (cell death without PCD type I and II features) [9]

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For example, glutamate dehydrogenase (GDH), an enzyme involved in amino acid metabolism, was hypomethylated for HC in comparisons with CH and HH oysters