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Acknowledgments The authors thank Meira Ben-Gad for editorial assistance

The second wave, in the 1980s and 1990s, was largely French and centered on the Maquart and Borel groups working on connective-tissue biology

1.0 mL Syringe: 100 units max ideal for large reconstitution volumes or doses over 50 units

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Collagen synthesis requires amino acids, particularly glycine, proline, and hydroxyproline