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ASDs, encompassing full-syndrome autism (autistic disorder), Asperger syndrome, tuberous sclerosis, Angel man syndrome, congenital rubella, Down syndrome, Rett syndrome, asphyxia, childhood disintegrative disorder, and pervasive developmental disorder not otherwise specified (PDDNOS), are now grouped as ASDs, also known as pervasive developmental disorders (PDDs)

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Fumarate accumulation in the Tricarboxylic Acid (TCA) cycle within mitochondria triggers a robust inflammatory response, impairing mitochondrial function [8, 9]

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Cells were washed and resuspended in FACS buffer and analyzed on an LSR Fortessa (BD Biosciences) operated on BD FACSDiva software (v9.0)

Biological sources of INPs include pollen 14,15,16,17 , phytoplankton 18,19 , Archaea 20 , Bacteria 21,22 , fungi 23,24,25 , and viruses 26