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The decline reduces sirtuin activity and sirtuins are the proteins that, when active, support healthy gene expression, metabolic flexibility and inflammatory balance

Mitochondrial damage is recognized as a central factor contributing to PD neuropathology, and loss of function mutations in tensin homolog (PTEN)-induced kinase 1 (PINK1) and parkin, two proteins involved in the clearance of damaged mitochondria through mitophagy, are involved in the neuropathology of inherited PD (Kitada et al., 1998

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J., Kuang, L

Prolactin Inhibiting Factor: Inhibits the release of prolactin and is probably dopamine which is secreted by the tuberoinfundibular neurons

Nat Cell Biol 2008