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Inflammation and disruption of the mucosal architecture in claudin-7-deficient mice

In neurodegenerative diseases, such as ALS, AD, and MS, the persistent strong proliferative response of microglia is a crucial part of these basic pathological processes [183]

Namely, redox-active metals, like Fe 2+ , react with peroxides generating highly active hydroxyl radicals (R-HO ) that further propagate the peroxidation reaction ( Cysteine, Lipid Peroxides and Ferroptosis Glutathione-Dependent Ferroptosis Since characterization of ferroptosis in 2012, the cysteine-GSH-GPx4 axis is described as essential pathway for its regulation, and thus seen as potential therapeutic target

Ames 1978)

The anticancer monosaccharide xylitol (100) and natural Chinese herbal extracts, including dihydroartemisinin (66), artesunate (67), glaucocalyxin A (140), and tanshinone IIA (162), upregulate Prostaglandin-Endoperoxide Synthase 2, p53 and ChaC1 expression

doi: 10.1016/j.curtheres.2014.01.001 [17] Jacobson Bensky M, Ayalon-Dangur I, Ayalon-Dangur R et al