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Adipocyte Gi signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity

Nat Rev Microbiol 7:845855 Beites T, Jansen RS, Wang R, Jinich A, Rhee KY, Schnappinger D, Ehrt S (2021) Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection

They have been linked with a smaller but significant risk of developing breast cancer (54)

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A recent study also shows that blocking IGF1R-mediated signaling reduces cell proliferation and increases cells sensitivity to the destructive effects of ionizing radiation mediated by down-regulation of BRCA2, a mediator of HR, suggesting that IGF1R is a target for enhancing tumor sensitivity to radiotherapy (Venkatachalam et al., 2017)