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However, because much of L-arginine is metabolized before reaching the endothelium, L-citrulline supplementation is recommended instead

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An ongoing phase Ib trial (NCT04167540) is designed to evaluate the safety and potential clinical effect of MRI-guided intraputaminal delivery of AAV2-GDNF in two cohorts of patients with either early-stage or advanced PD, thus contributing with important knowledge on the therapeutic effect early in PD course