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The composite picture from these Russian trials is a compound that lowers anxiety while preserving or even supporting cognition, at doses of 1.5 to 2.25 mg total daily (delivered as 0.15 percent nasal drops, 2 to 3 drops per nostril, three times daily)

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found that base modification could considerably reduce the hepatotoxicity of gapmer ASO, 245 providing insights for developing new gapmer ASOs

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doi:10.3748/WJG.V13.I22.3027 12