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The loss of SCFA-producing intestinal microbes would disrupt the equilibrium of glucose metabolism, raising the risk of CVD (27)

In addition, congestion, bleeding, or obstruction in the nose following TBI may prevent intranasal administration

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The mechanism by which probiotics exert their positive effects is still not known but it is though that they might influence neuroactive metabolites like gamma-aminobutyric acid and serotonin (Israelyan and Margolis, 2018)

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