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When B12 is deficient, demyelination occurs, particularly affecting the spinal cord's posterior columns (responsible for proprioception and vibration sense) and lateral corticospinal tracts (controlling motor function)

Protection of vascular endothelium stabilizes cell membranes and limits capillary degradation

Methadone , a full opioid agonist, has decades of evidence supporting its effectiveness, particularly in cases of high-severity opioid dependence

Guidelines and Protocols Advisory Committee: Cobalamin (vitamin B12) Deficiency - Investigation & Management [Internet]

If you've had a BAD experience with B12 shots, it's most likely that you do not tolerate or convert cyanocobalamin well (see if you can verify what form of B12 was in the shot that made you react poorly, and then stay away from that specific form if you can)