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The progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta leads directly to dopamine deficiency, underpinning the hallmark motor symptoms such as bradykinesia, resting tremor, and rigidity, as well as contributing to nonmotor symptoms including autonomic, mood, and cognitive disorders [2]

Effects of ACR and MEL on 8-OHdG expression in brain tissue The expression of 8-OHdG in brain tissues, with negative scores observed in the control and MEL20 groups

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Sanz-Ortega, J., Vocke, C., Stratton, P., Linehan, W