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Nat Rev Immunol 5:331342 Luo L, Schomaker S, Houle C, Aubrecht J, Colangelo JL (2014) Evaluation of serum bile acid profiles as biomarkers of liver injury in rodents

M pro and PLP are both involved in proteolytic processing of the large pp1a and pp1ab polyproteins to produce functional polypeptides, which assemble into the replicase-transcriptase complex (Zhang et al., 2020

Dogs treated with pyridoxine obtained a median cumulative dose of 4.7 mg/kg (mean, 4.1 mg/kg) compared to the 5.0 mg/kg cumulative goal dose, while dogs treated with placebo received a median of 2.75 mg/kg (mean, 2.9 mg/kg

The response to genetic ( UBE2I KD ) or pharmacological (ML792 and SAMe) inhibition of SUMOylation was assessed in vitro and in two in vivo models of CCA

Nevertheless, there comes a stage when the hair follicle loses its connection to the tiny skin muscles known as arrector pili muscles

Hepatocyte organoid culture For hepatocyte organoid cultures, the isolated PHHs (EpCAM-negative fraction) were mixed with Matrigel (Corning) or BME2 (AMSBIO), and 12,50050,000 cells were seeded in 50-l domes per well in 24-well plates and incubated at 37 C and 5% CO 2