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There are a few common, mild side effects associated with B12 shots, including: Mild diarrhea, itching, nausea and vomiting, dizziness, headaches, and hot flashes Redness or swelling at the injection site Temporary soreness at injection site Serious side effects are rare but require immediate medical attention

This is a localized reaction with redness, pain, tenderness, and swelling at the injection site that occurson average seven to 10 days after vaccination , says Hana El Sahly, M.D., an associate professor of molecular virology and microbiology at Baylor College of Medicine in Houston and a national co-principal investigator of the phase 3 clinical trial for the Moderna vaccine

Also, it is worth noting that oral medication can be used to easily manage any initial discomfort