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Together, these findings demonstrate that, in contrast with acute exposure, chronic disruption of iron homeostasis with consequent GSH depletion remodels cellular redox homeostasis over time, inducing a state we term chronoferroptosis: a persistent ferroptotic adaptation characterized by coordinated alterations in iron-handling and antioxidant defense proteins that may represent early vulnerability to neurodegenerative pathology

3.7 Cutting-edge directions and future prospects of astrocytic metabolism research In conclusion, while astrocytes have long been recognized for their supportive roles in the brain, current research is increasingly highlighting their active participation in brain energy metabolism and their potential involvement in neurological disorders

longum as a potential modulator of elderly innate immunity

Several studies have reported that more than one strategy is needed to address the delivery challenges

During EMT conversion, activated Zeb1 increases the synthetic levels of PUFAs, which increases the levels of active lipid peroxides, enhancing the sensitivity of tumor cells to ferroptosis

By delving deeply into the mechanisms of disrupted lipid metabolism, novel biomarkers and therapeutic targets can be uncovered, laying the groundwork for precision treatments in COPD