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However, in this case, activation of the AKT/mTOR signaling pathway to inhibit autophagy is also recognized as an alternative protective mechanism (162)

Because it is gentle, it is less likely to cause the stinging or peeling associated with stronger actives

In their research, they applied the Pavia Protocol consisting of 150 mg/kg intravenous NAC followed by 300 mg/kg/day until 48 h after poisoning, alongside forced diuresis until negative urinary amanitin levels were obtained

This significantly enhanced the accumulation of cisplatin in tumor cells, increasing efficacy in cisplatin resistant cells and decreased tossicity 95

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