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ChaC-like enzymes act specifically on GSH, GGACT enzymes act on -glutamylamine amino acids, and GGCTs have a broader activity towards -glutamyl amino acids in general

342,343,344 Finally, the systemic chronic inflammation resulting from immunosenescence and non-neurotropic viral infection compels immune cells in the peripheral blood to penetrate the blood-brain barrier (BBB) and choroid plexus and enter the brain, 345,346 Additionally, immune cells originating from the cranial bone marrow migrate to the meninges, 347 thereby promoting neuroinflammation and neuronal dysfunction while inhibiting neurogenesis

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This massive trial aims to map the exact restoration of brain GSH and assess exact symptom improvements, potentially establishing NAC as a standard-of-care intervention for the profound neuroinflammation seen in ME/CFS