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TNF-a and IL-6 have, in separate studies, both been identified as potentially key immune factors in ME/CFS The authors go on to note that, in some cases, mental fatigue persists long after the identified neural trauma has been resolved (perhaps due to a genetic predisposition or due to dendritic remodelling) and emphasise the importance of early treatment to prevent the problem becoming chronic : Providing information about mental fatigue, its cause and the prognosis, is of utmost importance for breaking the vicious circle, which comes with the risk for secondary anxiety and depression

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Melanocortin agonism stimulates melanocytes, and a related report describes eruptive nevi a sudden crop of new moles associated with an -MSH analog, exactly the kind of pigment-cell proliferation one would predict from over-stimulating this pathway

Interestingly, this system enhanced the elimination of both CSCs and non-CSCs from liver cancer cells both in vitro and in vivo

Verifiable Phase 2 data beat unpublished Phase 3 toplines