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Cytokeratin 18 (CK18), a type I cytokeratin of the intermediate filament family, is essential for withstanding external cellular stresses and maintaining cellular structural integrity

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Together, findings from these two studies [25, 28] may suggest that antidepressants should generally not be used in two-thirds of patients with bipolar depression who present with subtly increased psychomotor tempo, pressured speech and racing thoughts

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