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Several studies analyzed the exo-metabolome in culture media to examine hepatotoxic effects of xenobiotics ( The analysis of the exometabolome is a valuable tool for evaluating drug-induced liver damage, particularly in cases where obtaining a liver sample from DILI patients is not feasible for medical and ethical reasons

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Since the implications of GPX3 in cancer have been well documented and extensively reviewed [23,24], this issue is beyond the scope of this paper, and this paper will focus primarily on its roles outside of oncology