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Finally, 20 articles met the inclusion criteria for this review

In diabetes, oxidative stress exacerbates complications like diabetic retinopathy and nephropathy by impairing cellular functions and promoting inflammatory responses

Rutka, J

doi: 10.3389/fimmu.2022.913854 169 KhanMZLiuLZhangZKhanAWangDMiSet al

597 In addition, bioinformatics analysis shows that Nrf2 is the target of FTO, and FTO impairs Nrf2 mRNA stability through an m6A dependent pathway, revealing the potential function of FTO in PD neurological diseases

In both humans and rodents, acute bouts of endurance exercise typically elevate circulating irisin levels by 23-fold, with reported concentrations ranging from ~3 to 10 ng/mL in serum 34