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Collectively, NNT is therefore a key enzyme bridging cell metabolism and reductive stress

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As discussed in previous chapters, the resistance to tamoxifen is mediated through various mechanisms

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In this study, we performed a phenotypic screen of a 180-compound natural product library and identified (20S)-protopanaxatriol ((20)S-APPT), a ginsenoside derivative, as a potent ferroptosis inducer with a favorable safety profile both in vitro and in vivo

The formation of is an irreversible process catalyzed by pseudouridine synthases (PUS) via two distinct pathways: a protein-only mechanism mediated by PUS enzymes and an RNA-dependent mechanism involving box H/ACA ncRNAs and the Cbf5/dyskerin complex [103]