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In fact, sometimes, if analyzed carefully, their results can be inconclusive: in the same work cited above, in some types of cancer, therapy with polyphenols did not change the incidence of the disease, or in some cases, it even worsened [158]

but, at the high dose (8 mg/kg/day), most of the animals succumbed by the end of the first week of treatment and others that survived presented signs of peritonitis [329]

In addition, future research also needs to focus on mtDNA segregation in tissues, due to genetic drift in mtDNA segregation, and observations show that this drift is tissue-specific

The reduction by dutasteride of prostate cancer events (REDUCE) trial is another multicenter, randomized, international, placebocontrolled, double blind clinical trial initiated in 2003 to evaluate the ability of dutasteride to decrease the risk of biopsy detectable prostate cancer in men with moderately elevated PSA levels

Therefore, we intend to characterize the two bands in more detail to understand the enzymatic regulation of Chac1 in our future study

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