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Based on the considerations mentioned above, it seems reasonable that the proinflammatory cytokine IL-17 interferes with insulin signaling and insulin sensitivity (Figure 2) and contributes to adipoflammation and metaflammation in obesity and diabetes (139)

10.1016/j.jacc.2011.06.063 172 MucciL

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Thus, SARS-CoV-2 proteins could sense the host cellular metabolic status and trigger human metabolic reprogramming/dysregulation (HMRD) in the infected human host