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In Pgam5 -deleted mice, it counterproductively promoted mitochondrial fusion, leading to intracellular ROS accumulation as well as oxidative stress, thus accelerating RPE cell senescence, in which the IRF/IFN- pathway was also observed, which may be related to cell senescence

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These observations suggest that glutathione induces aerobic metabolism and improves an acidic environment in skeletal muscle during exercise by elevating PGC-1, which would prevent exercise-induced fatigue

Dorsey, J

(Cham, Switzerland: Springer International Publishing), 253268